abstract：OBJECTIVE:Management of locally advanced cervical cancer consists primarily of combination external and internal radiation. In order to investigate the impact of intracavitary brachytherapy versus interstitial brachytherapy on local tumor control, survival, and complications, we retrospectively reviewed the concomitant...

journal_title：Gynecologic oncology

authors： Monk BJ,Tewari K,Burger RA,Johnson MT,Montz FJ,Berman ML

更新日期：1997-12-01 00:00:00

abstract：:Aggressive tumor reduction surgery has been widely used in patients with advanced stage epithelial ovarian carcinoma before initiation of cytotoxic chemotherapy. No randomized controlled trial has been carried out to confirm the benefits of such procedures. To examine the role of cytoreductive surgery in the managemen...

journal_title：Gynecologic oncology

authors： Le T,Krepart GV,Lotocki RJ,Heywood MS

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:The objective was to determine the frequency with which regression or progression of disease without treatment occurred in women diagnosed with squamous cell cervical carcinoma in situ (CIS) during pregnancy. METHODS:. A retrospective chart review of all women evaluated at the University of Iowa Colposcopy C...

journal_title：Gynecologic oncology

authors： Coppola A,Sorosky J,Casper R,Anderson B,Buller RE

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:The host-tumor interactions and tumor stroma may participate in the regulation of invasive behavior of tumor cells. In order to better understand the human ovarian cancer invasion we explored the possibility that normal fibroblasts could participate in the control of the spread of human ovarian cancer. RESUL...

journal_title：Gynecologic oncology

authors： Westerlund A,Hujanen E,Puistola U,Turpeenniemi-Hujanen T

更新日期：1997-10-01 00:00:00

abstract：:This study evaluated the effect ovarian weight has on the accuracy of frozen sections in serous and mucinous ovarian tumors. The study group included 294 patients who had an initial frozen section (189 serous and 105 mucinous tumors) at surgery. The pathology reports were separated into subgroups (benign, borderline, ...

journal_title：Gynecologic oncology

authors： Puls L,Heidtman E,Hunter JE,Crane M,Stafford J

更新日期：1997-10-01 00:00:00

abstract：:A case of Stage IIIC primary ovarian leiomyosarcoma in a premenopausal woman with multiple recurrences alive and well 7 years after diagnosis is presented. In addition to the typical light microscopic, immunohistochemical, and electron microscopic features of ovarian leiomyosarcoma, the tumor was progesterone receptor...

journal_title：Gynecologic oncology

authors： Rasmussen CC,Skilling JS,Sorosky JI,Lager DJ,Buller RE

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether alteration of BRCA1 tumor suppressor gene occurs in sporadic endometrial carcinomas. METHODS:Genomic DNAs were prepared from 33 consecutively collected endometrial carcinoma tissues for BRCA1 mutational analysis. To screen for BRCA1 mutation, polymerase chain reaction (PCR) amplificati...

journal_title：Gynecologic oncology

authors： Liu FS,Ho ES,Shih RT,Shih A

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine if DNA ploidy, hormone receptors, vascular space invasion (VSI), perivascular lymphocytes (PVL), and the oncogenes HER-2/neu, p53, and bcl-2 are independent prognostic indicators for lymph node metastasis and cancer recurrence in clinical stage I endometrial carcinoma. METHODS:Among 349 patients...

journal_title：Gynecologic oncology

authors： Bell JG,Minnick A,Reid GC,Judis J,Brownell M

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To evaluate the long-term disease control, survival and complication rates using high-dose-rate intracavitary brachytherapy (HDRB) and external beam radiotherapy (EBRT) for patients found to have isolated vaginal recurrences from early-stage endometrial adenocarcinoma following total abdominal hysterectomy and ...

journal_title：Gynecologic oncology

authors： Pai HH,Souhami L,Clark BG,Roman T

更新日期：1997-08-01 00:00:00

abstract：:We have previously reported an overall response rate of 41% and a median survival duration of 14 months in a series of 49 patients with metastatic or recurrent endometrial carcinoma treated by a combination of etoposide, 5-fluorouracil, and cisplatin. In order to increase response rate and survival duration, doxorubic...

journal_title：Gynecologic oncology

authors： Pierga JY,Diéras V,Beuzeboc P,Dorval T,Palangié T,Jouve M,Scholl SM,Garcia-Giralt E,Pouillart P

更新日期：1997-08-01 00:00:00

abstract：:Cervical intraepithelial neoplasia grade 3 (CIN 3) is treated surgically. Follow-up of these patients is important to ensure successful treatment. The present study was undertaken to determine whether human papillomavirus (HPV) testing can be used to discriminate patients who will have recurrences from those who will ...

journal_title：Gynecologic oncology

authors： Chua KL,Hjerpe A

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To report a series of cases of hepatic resection for metastatic gynecologic carcinomas. METHODS:We reviewed the records of all patients who underwent hepatic resection for metachronous liver metastases from gynecologic carcinomas at our institution from 1986 to 1996. RESULTS:Twelve patients were identified ...

journal_title：Gynecologic oncology

authors： Chi DS,Fong Y,Venkatraman ES,Barakat RR

更新日期：1997-07-01 00:00:00

abstract：:Primary lymphoma of the uterine corpus (PLUC) is an extremely rare neoplasm. We report a case of PLUC in a 78-year-old woman with vaginal bleeding without hepatosplenomegaly, adenopathies, or bone marrow infiltration, classified as stage I. A diagnosis of diffuse large B-cell lymphoma was made in endometrial curettage...

journal_title：Gynecologic oncology

authors： Alvarez A,Ortiz JA,Sacristán F

更新日期：1997-06-01 00:00:00

abstract：:Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papi...

journal_title：Gynecologic oncology

authors： Romney SL,Ho GY,Palan PR,Basu J,Kadish AS,Klein S,Mikhail M,Hagan RJ,Chang CJ,Burk RD

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency of cervical cytologic/histologic discrepancies in a group of obstetric patients diagnosed as HIV infected by routine prenatal screening. Also, to determine if serum CD4 levels or sexually transmitted diseases (STDs) are associated with the occurrence of preinvasive cervical disease i...

journal_title：Gynecologic oncology

authors： Robinson WR,Barnes SE,Adams S,Perrin MS

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:To propose a risk-specific follow-up protocol for endometrial carcinoma patients. METHODS:A retrospective cohort of endometrial carcinoma patients was used to identify risk factors for recurrence. Based on a profile of risk factors, women were classified at either low or high risk for recurrence (median foll...

journal_title：Gynecologic oncology

authors： Shumsky AG,Brasher PM,Stuart GC,Nation JG

更新日期：1997-06-01 00:00:00

abstract：:To determine the effects of neoadjuvant chemotherapy (NAC) in the management of cervical carcinoma Stage IB2 (tumor diameter > 4 cm), we reviewed 52 surgically treated patients diagnosed between January 1987 and December 1993. There were 20 patients treated with preoperative neoadjuvant chemotherapy and 32 treated by ...

journal_title：Gynecologic oncology

authors： Serur E,Mathews RP,Gates J,Levine P,Maiman M,Remy JC

更新日期：1997-05-01 00:00:00

abstract：:The single most common cause leading to the diagnosis of endometrial cancer is postmenopausal bleeding. Although most patients with early-stage disease (FIGO stage I and II) can be cured, prognosis worsens considerably with increasing stage. While serum CA 125 levels are elevated only in a significant proportion of pa...

journal_title：Gynecologic oncology

authors： Beck EP,Wagner M,Anselmino L,Xu F,Bast RC Jr,Jaeger W

更新日期：1997-05-01 00:00:00

abstract：:The retinoblastoma (RB) gene was the first defined tumor suppressor gene. While originally described in retinoblastoma, more recently alterations in RB have been described in a number of other human neoplasms and there has been a suggestion that alteration of RB may play a significant role in the development of endome...

journal_title：Gynecologic oncology

authors： Niemann TH,Yilmaz AG,McGaughy VR,Vaccarello L

更新日期：1997-05-01 00:00:00

abstract：:Iatrogenic immune suppression following renal transplantation is frequently associated with certain neoplasms, including vulvar carcinoma. We describe a patient with a vulvar carcinoma less than 1 mm depth of invasion and less than 3 mm superficial spread 12 years after renal transplantation. A simple vulvectomy was p...

journal_title：Gynecologic oncology

authors： Volgger B,Marth C,Zeimet A,Müller-Holzner E,Ruth N,Dapunt O

更新日期：1997-04-01 00:00:00

abstract：:The objective of this study was to evaluate the prognostic value of a convenient nuclear grading system based on only the proportion of nuclei measuring more than 10 microm in length at the shortest axis in endometrial carcinomas. Of the 235 cases reviewed, 9 serous and 5 clear cell adenocarcinomas and 2 small cell ca...

journal_title：Gynecologic oncology

authors： Hachisuga T,Kawarabayashi T,Iwasaka T,Sugimori H,Kamura T,Tsuneyoshi M

更新日期：1997-04-01 00:00:00

abstract：UNLABELLED:Misconceptions about cancer may increase the level of fear in the general public and render coping more difficult in cancer patients. The aim of this survey was to study the level of knowledge and misconceptions. MATERIALS AND METHODS:A questionnaire comprising 27 questions related to cancer etiology, treat...

journal_title：Gynecologic oncology

authors： Carlsson ME,Strang PM

更新日期：1997-04-01 00:00:00

abstract：:It is very rare to find endometrial cancers arising within a short period following childbirth, presumably because pregnancy has a protective effect against endometrial cancer mediated by elevated secretion of progesterone. We present the case of a 30-year-old Japanese woman with stage IIIC endometrial cancer that was...

journal_title：Gynecologic oncology

authors： Kodama J,Yoshinouchi M,Miyagi Y,Kobashi Y,Kamimura S,Okuda H,Kudo T

更新日期：1997-03-01 00:00:00

abstract：:All patients with bulky (> or =4 cm) Stage Ib or IIa cervical carcinoma treated at Chang Gung Memorial Hospital between August 1988 and December 1991 using a strategy of neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical hysterectomy were reviewed. Fifty-nine evaluable patients received 1 ...

journal_title：Gynecologic oncology

authors： Lai CH,Hsueh S,Chang TC,Tseng CJ,Huang KG,Chou HH,Chen SM,Chang MF,Shum HC

更新日期：1997-03-01 00:00:00

abstract：:The purpose of this study was to evaluate the differences of blood supply in benign and malignant breast tumors by color Doppler flow measurements. The study included 471 patients, 133 with carcinomas, 325 with benign breast lesions, and 13 with mastitis. An ATL UM9/HDI was used with an electronic 10-MHz linear array ...

journal_title：Gynecologic oncology

authors： Madjar H,Sauerbrei W,Prömpeler HJ,Wolfarth R,Gufler H

更新日期：1997-03-01 00:00:00

abstract：:In an attempt to characterize the molecular alterations of cervical adenocarcinoma, we analyzed 32 paraffin-embedded specimens for the presence of K-ras mutations, p53 overexpression, p16 and Rb protein expression, and the presence of HPV 16 and 18 DNA. Overall 25/32 (78%) of the tumors displayed an abnormality in at ...

journal_title：Gynecologic oncology

authors： Parker MF,Arroyo GF,Geradts J,Sabichi AL,Park RC,Taylor RR,Birrer MJ

更新日期：1997-02-01 00:00:00

abstract：:Arterial thromboembolic disease almost always occurs in the setting of significant cardiovascular disease. Fewer than 10% of patients have no known etiology and only rarely is malignancy implicated. A review of the literature revealed only one prior report associated with a gynecologic malignancy, and this occurred in...

journal_title：Gynecologic oncology

authors： Minjarez DA,Delorit MA,Davidson SA

更新日期：1997-01-01 00:00:00

abstract：:In order to determine the efficacy and toxicity of the gonadotrophin-releasing hormone agonist Leuprolide in the management of patients with recurrent or metastatic endometrial cancer, we performed a phase II study. Patients were included if there was clinical or radiological documentation of bidimensionally measurabl...

journal_title：Gynecologic oncology

authors： Covens A,Thomas G,Shaw P,Ackerman I,Osborne R,Lukka H,Carey M,Franssen E,Roche K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To perform a phase I study of topically applied dihematoporphyrin ether (DHE) in the photodynamic treatment (PDT) of cervical intraepithelial neoplasia (CIN) using fixed DHE doses and application schedules, and a variable dose of 630 nm red light delivered by an argon-pumped dye laser. METHODS:Between Februa...

journal_title：Gynecologic oncology

authors： Monk BJ,Brewer C,VanNostrand K,Berns MW,McCullough JL,Tadir Y,Manetta A

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of surgical debulking performed on patients with Stage IV ovarian cancer and to determine prognostic factors which identify pts who may benefit from aggressive initial surgical debulking. METHODS:A retrospective chart review was conducted (1/1/87-12/31/93). Eligible patients include...

journal_title：Gynecologic oncology

authors： Curtin JP,Malik R,Venkatraman ES,Barakat RR,Hoskins WJ

更新日期：1997-01-01 00:00:00

abstract：:Symptomatic uterine lymphangioleiomyomatosis (LAM) simulating high-stage uterine sarcoma in a patient with tuberous sclerosis complex is reported. A 49-year-old female presented with abdominal pain and anemia. Preoperative workup revealed a uterine mass and a large amount of peritoneal free fluid and possible metastat...

journal_title：Gynecologic oncology

authors： Longacre TA,Hendrickson MR,Kapp DS,Teng NN

更新日期：1996-12-01 00:00:00

abstract：:Twenty-nine women, ages 30-58 years, with advanced ovarian carcinoma were treated with a developmental combination chemotherapy regimen consisting of mitomycin C, etoposide, cisplatin, and carboplatin (MECCA). This protocol utilized the concepts of dose intensity, front-end loading, non-cross-resistance, and synergy. ...

journal_title：Gynecologic oncology

authors： Hoskins PJ,Swenerton KD,Pike JA,McMurtrie EM,Lee N

更新日期：1996-12-01 00:00:00

abstract：:A 46-year-old woman with the complaint of hypermenorrhea underwent hysterectomy for a presumed uterine myoma. The solid tumor in the myometrium was gray in color, was 4 cm in diameter, and showed hemorrhage and necrosis. Histologically, the tumor consisted of round or polygonal cells arranged in cords and nests, and i...

journal_title：Gynecologic oncology

authors： Kuroda H,Konishi I,Nanbu K,Mandai M,Komatsu T,Yamamoto S,Yamabe H,Kida A,Mori T

更新日期：1996-11-01 00:00:00

abstract：:Immunohistochemical studies were performed to investigate the prognostic significance of p53 protein expression in 46 patients with stage IIIB squamous cell carcinoma of the uterine cervix who were treated with radiation therapy alone. Tumor cells showed p53 protein expression in 29 of 46 patients. The 5-year overall ...

journal_title：Gynecologic oncology

authors： Ebara T,Mitsuhashi N,Saito Y,Sakurai H,Hasegawa M,Takahashi M,Takahashi T,Hayakawa K,Niibe H

更新日期：1996-11-01 00:00:00

abstract：:Twenty-eight patients with advanced, persistent or recurrent leiomyosarcoma of the uterus not previously exposed to cytotoxic drugs were entered into a study of single-agent intravenous etoposide 100 mg/m2 daily for 3 days every 3 weeks. No complete or partial responses were observed. Thirteen patients demonstrated st...

journal_title：Gynecologic oncology

authors： Thigpen T,Blessing JA,Yordan E,Valea F,Vaccarello L

更新日期：1996-10-01 00:00:00

abstract：:The response rate and the determinants of response to a cisplatin-based regimen of neodjuvant chemotherapy (NACT) in women with a histologically confirmed first-diagnosis of invasive bulky stage IB-IIB cervical cancer are analyzed. A total of 79 cases were treated with cisplatin (40 mg/m2) each 7 days for seven course...

journal_title：Gynecologic oncology

authors： Bolis G,van Zainten-Przybysz I,Scarfone G,Zanaboni F,Scarabelli C,Tateo S,Calabrese M,Parazzini F

更新日期：1996-10-01 00:00:00

abstract：:A 58-year-old postmenopausal woman with primary ovarian serous carcinoma presented with the syndrome of inappropriate antidiuresis (SIAD). Preoperative workup showed serum sodium level of 110 mEq/liter and antidiuretic hormone level of 3.3 pg/ml. The serum and urine osmolarity were 239 and 371, respectively. Antidiure...

journal_title：Gynecologic oncology

authors： Taskin M,Barker B,Calanog A,Jormark S

更新日期：1996-09-01 00:00:00

abstract：:Experience with the P.A.S.-PORT, a peripherally implanted central venous access device, is evaluated in a retrospective review of 154 patients from July 1991 to June 1994. Blood could not be aspirated from six patients. Complications included temporary minor thrombophlebitis in seven patients (4.5%), symptomatic axill...

journal_title：Gynecologic oncology

authors： Deppe G,Kahn ML,Malviya VK,Malone JM Jr,Christensen CW

更新日期：1996-09-01 00:00:00

abstract：:The oncogene specific mRNA of c-erbB-2 was detected by the S1 nuclease protection assay in 95 ovarian cancer specimens. In 79 primary carcinomas, we found 16 (20%) with strong expression, 13 (17%) with weak expression, 4 (5%) with very weak expression, and 46 (58%) with no expression. In 3 of 16 recurrencies (19%) a s...

journal_title：Gynecologic oncology

authors： Tanner B,Kreutz E,Weikel W,Meinert R,Oesch F,Knapstein PG,Becker R

更新日期：1996-08-01 00:00:00

abstract：:Less extensive surgical treatment has become possible for limited vulvar cancer. However, primary closure is advisable only when the defect is minimal and tissue replacement is always needed in radical excisions. Local flaps are always considered the first choice because of their characteristics of similarity to the r...

journal_title：Gynecologic oncology

authors： Tateo A,Tateo S,Bernasconi C,Zara C

更新日期：1996-08-01 00:00:00